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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 1071-1075

Antitumor activity of Pogostemon benghalensis Linn. on ehrlich ascites carcinoma tumor bearing mice


1 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Guwahati, India
2 Department of Pathology, Gauhati Medical College and Hospital, Guwahati, Assam, India
3 Department of Pharmaceutical Chemistry, Swamy Vivekanandha College of Pharmacy, Elayampalayam, Tiruchengodu, Namakkal, Tamil Nadu, India

Correspondence Address:
Manish S Patel
NIPER-Ahmedabad, C/O B. V. Patel, PERD Centre, SG Highway, Thaltej, Ahmedabad - 380 054, Gujarat
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.138014

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Background: Pogostemon benghalensis has been used traditionally as anticancer in India. Aim of the Study: The present study was undertaken to investigate the antitumor activity of hydroethanolic extract of P. benghalensis (HEEPB) and aqueous extract of P. benghalensis (AEPB) on ehrlich ascites carcinoma (EAC) tumor bearing mice. Materials and Methods: For antitumor effect, treatments with HEEPB and AEPB at doses of 250 mg/kg and 500 mg/kg/day orally were started after 24 h of intraperitoneal inoculation of EAC cells. After the treatment period, median survival time (MST), hematological parameters and solid tumor volume were used to evaluate antitumor activity of the extracts. Results: Both, HEEPB and AEPB, have increased MST (P < 0.05), reduced solid tumor volume (P < 0.05) and normalized hematological parameters (P < 0.05) significantly. Conclusion: As HEEPB and AEPB were effective in reducing the severity of morphological and biochemical parameters induced by EAC cells, this study justifies the traditional use of this plant in cancer.

Abstract in Chinese

广鹬(Pogostemon benghalensis Linn对艾氏腹水癌荷瘤小鼠的抗肿瘤活性 摘要 背景:在印度广鹬已被传统地用于抗癌。 研究目的:本研究的目的是探讨广鹬水乙醇提取物(HEEPB)和广鹬水提取物(AEPB)对艾氏腹水癌(EAC)荷瘤小鼠的抗肿瘤活性。 材料和方法:腹腔接种EAC细胞后24小时开始,分别予每天250 mg/kg和500 mg/kg 的剂量口服HEEPB 和 AEPB来对抗肿瘤。治疗后,中位生存时间(MST),血液学参数和实体肿瘤体积被用来评价提取物的抗肿瘤活性。 结果:HEEPB 和 AEPB都显著增加了MST(P<0.05),减小了肿瘤体积(P<0.05)和正常化了血液学参数(P<0.05)。 结论:HEEPB 和 AEPB减少了EAC细胞诱导的形态学严重程度和生化参数,这项研究证明这种植物的在癌症的传统作用。 关键词:艾氏腹水癌,中位生存时间,广鹬,实体肿瘤



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