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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 1052-1056

Prognostic significance of metastasis associated in colon cancer 1 (MACC1) expression in patients with gallbladder cancer


1 Department of Gastroenterology, Lishui City Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, P.R. China
2 Department of General Surgery, Guangfu Hospital of Jinhua, Jinhua, P.R. China
3 Department of General Surgery, Shanxi Medical University Second Hospital, Taiyuan, P.R. China
4 Department of Gastroenterology, Shanxi Medical University Second Hospital, Taiyuan, P.R. China

Correspondence Address:
Bin Ye
Department of Gastroenterology, Lishui City Central Hospital and the Fifth Affiliated Hospital of Wenzhou Medical University, 289 Kuocang Road, Lishui, Zhejiang - 323000
P.R. China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.137977

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Background: The clinical significance of metastasis associated in colon cancer 1 (MACC1), in human gallbladder cancer, is not yet established. This study was performed to assess the expression of MACC1 in benign and malignant gallbladder lesions, and to assess its clinicopathological significance. Materials and Methods: Tissue samples from resected gallbladder cancer (n = 70) and cholelithiasis (n = 70) were evaluated for MACC1 expression by immunohistochemical staining. Their expression was correlated with different clinicopathological parameters. Results: Cytoplasmic MACC1 expression was significantly higher (58.6%) in gallbladder cancer than in chronic cholecystitis (27.1%, P < 0.001). High MACC1 levels were associated with lymph node metastasis (P < 0.05), tumor node metastasis (TNM) stage (P < 0.01), and perineural invasion (P < 0.01), but not with sex, age, history of gallstones or histological grade (P > 0.05). The univariate Kaplan-Meier analysis showed that a positive MACC1 expression was associated with decreased overall survival (P < 0.001). The multivariate Cox regression analysis showed that MACC1 expression and the histopathological subtypes were independent risk factors for disease-free survival. Conclusion: The expression of MACC1 might be closely related to carcinogenesis, clinical biological behaviors, and prognosis of gallbladder adenocarcinoma.

Abstract in Chinese

胆囊癌患者结肠癌转移相关基因1(MACC1)表达的预后意义 摘要 研究背景:结肠癌转移相关基因1(MACC1)在胆囊癌的临床意义尚未确立。本研究的目的是评估胆囊良、恶性病变中MACC1表达,探讨其临床病理学意义。 材料与方法:通过对切除胆囊癌组织标本(n = 70)和胆石症标本(N = 70)进行免疫组化染色,评价MACC1基因的表达。他们的表达与不同的临床病理参数相关。 结果:胆囊癌中细胞质MACC1的表达(58.6%)显著高于在慢性胆囊炎中(MACC1的表达)(27.1%,P<0.001)。高MACC1水平与淋巴结转移(P<0.05),TNM分期(P<0.01),嗜神经侵袭(P<0.01)相关,但与性别,年龄,胆囊结石病史或肿瘤的组织学分级(无显著关联)(P>0.05)。单因素Kaplan-Meier分析表明MACC1表达与总生存率降低有关(P<0.001)。多因素Cox回归分析显示,MACC1的表达和组织病理学亚型均为无病生存率的独立危险因素。 结论:MACC1基因的表达可能与肿瘤发生,临床生物学行为,及胆囊腺癌预后密切相关。 关键词:胆囊癌,免疫组化,结肠癌转移相关基因1



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