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Year : 2014  |  Volume : 10  |  Issue : 4  |  Page : 1030-1032

Investigation on immune function and chest drainage in patients with thoracic malignancies using the streptococcal agent Sapylin

Department of Thoracic Surgery, Afflicted Hospital of Medical College, Qingdao University, China

Correspondence Address:
Kaihua Tian
16 Jiangsu, Qingdao266003
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.137983

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Purpose: To investigate the influence of Sapylin used during the operation on immune function and chest drainage in patients with thoracic malignancies in early postoperative period. Patients and Methods: Seventy-one patients with thoracic malignancies including lung cancer and esophageal carcinoma who underwent tumor resection were divided into two groups, 36 cases of observation group and 35 cases of control group. In observation group, Sapylin were locally laid in operation field during the operation. The control group was not given Sapylin. Drainage volume of chest cavity after operation, and the levels of CD4, CD8, CD4/CD8 and natural killer (NK) cell were recorded. Results: The level of CD4+, CD4+/CD8+ and NK cell in observation group were higher than that in control group (P < 0.05) wholly in early postoperative period. Drainage volume of chest cavity in observation group was less than that in control group postoperatively, 1160.2 ± 437.2 ml vs. 1363.3 ± 472.9 ml, but the change in two groups had no significance statistically (P = 0.064). Conclusions: The local application of Sapylin during operation can improve immunity of patients with thoracic malignancies significantly and decrease the drainage volume of chest cavity probably in early postoperative period. So it is worthy of popularizing in clinical practice.

Abstract in Chinese

胸部恶性肿瘤患者使用链球菌剂沙培林对免疫功能及胸腔引流 (影响)的调查 摘要 目的:探讨手术中使用沙培林对胸部肿瘤患者术后早期阶段免疫功能和胸腔引流的影响。 患者和方法:71例胸部肿瘤包括肺癌、食管癌行肿瘤切除术的患者分为两组,观察组36例,对照组35例。观察组术中在手术区域局部放置沙培林。对照组不给予沙培林。术后记录胸腔引流量,及CD4、CD8水平,CD4/CD8比和自然杀伤(NK)细胞数量。 结果:术后早期,观察组的CD4 +水平,CD4+/CD8+和NK细胞水平明显高于对照组(P<0.05)。观察组术后胸腔引流量少于对照组,1160.2±437.2毫升vs 1363.3±472.9毫升,但无统计学意义(P = 0.064)。 结论:沙培林术中局部应用可提高胸部恶性肿瘤患者免疫功能,可能明显降低术后早期胸腔引流量。值得在临床上推广应用。 关键词:引流量,免疫功能,术后阶段,沙培林,胸部恶性肿瘤

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