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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 3  |  Page : 531-534

Lack of human papillomavirus DNA in colon adenocarcinama and adenoma


1 Department of Clinical Research, Pasteur Institute of Iran, Tehran, Iran
2 Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
3 Pathology Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Iranian Society for Support of Patients with Infectious Diseases, Tehran, Iran

Correspondence Address:
Amitis Ramezani
Department of Clinical Research, Pasteur Institute of Iran,No 69, Pasteur Ave., Tehran, 13164
Iran
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Source of Support: This project was financially supported by Pasteur Institute of Iran, Conflict of Interest: None


DOI: 10.4103/0973-1482.137674

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Background: Human papilloma viruses (HPV) have been detected in several types of cancers. Over the last few years, a possible correlation between HPV infection and colon cancers has been suggested. The aim of this study was to assess the presence of HPV-DNA in colon adenocarcinomas and adenomas to describe the relationship of HPV infection with these pathologic features. Materials and Methods: The study included formalin-fixed and paraffin-embedded tissue samples of 70 patients with colon adenocarcinoma and 30 patients with adenoma (as study group) and 30 tumor adjacent tissues (as control). HPV-DNA was purified and first amplified through MY09/MY11 and GP5+/GP6+ primers. Subsequently, for more precision, another PCR was performed using PGMY09/11 L1 consensus primer system. Results: All tested adenocarcinomas and adenomas as well as normal tumor adjacent tissues were negative for all types of HPV in two PCR assays. Conclusion: Our results do not support the relationship between HPV infection and colon carcinoma or adenoma. Attributing a role to the HPV in the etiology of colon carcinogenesis will require further studies.


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