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CORRESPONDENCE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 399-400

Merkel cell carcinoma: A rare presentation


Department of Surgery, I.P.G.M.E. and R/S.S.K.M Hospital, Kolkata, West Bengal, India

Date of Web Publication14-Jul-2014

Correspondence Address:
Prosanta Kumar Bhattacharjee
Flat no. 5, 4th Floor, Suryatoran Apartments, 114/A, Barasat Road, Kolkata
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136670

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 > Abstract 

A 33-year-old man presented with a lump at the right side of chest wall of 4 months duration which started bleeding suddenly from an ulcer at its center. Examination revealed a globular ulcerated mass 2 cm in diameter, on the anterior axillary fold, with adherent clot at its center. No regional lymphadenopathy was noted. Wide local excision with 2 cm margin was done. Biopsy report revealed malignant small round-cell tumor. Immunohistochemistry showed it to be cytokeratin-20-positive and S100-negative, suggesting the diagnosis of Merkel cell carcinoma. The patient did not receive any other adjuvant therapy. He is being followed-up for the last 4 years and has shown no features of recurrence so far.

 > Abstract in Chinese 

一例罕见的默克尔细胞癌报道
摘要
患者男性,33岁,4个月前发现右胸壁有肿块,未引起重视。现该肿块中央溃疡出血。体格检查发现一个直径2cm的球形溃疡性肿块,腋前襞,中心有黏附的血凝块。没有发现区域淋巴结肿大。于病灶外缘2cm行扩大局部切除术。检查报告显示恶性小圆细胞肿瘤。免疫组化结果显示它是细胞角蛋白20阳性和S100阴性,表明默克尔细胞癌的诊断。患者没有接受任何其他的辅助治疗。近4年来他一直接受随访,目前为止没有复发。
关键词:默克尔细胞癌,根治性手术治疗,溃疡


Keywords: Merkel cell carcinoma, radical surgery, ulcer


How to cite this article:
Bhattacharjee PK, Halder SK, Ray RP. Merkel cell carcinoma: A rare presentation. J Can Res Ther 2014;10:399-400

How to cite this URL:
Bhattacharjee PK, Halder SK, Ray RP. Merkel cell carcinoma: A rare presentation. J Can Res Ther [serial online] 2014 [cited 2019 Jun 18];10:399-400. Available from: http://www.cancerjournal.net/text.asp?2014/10/2/399/136670


 > Introduction Top


In 1875, Friedrich S. Merkel first described human Merkel cells. [1] The term Merkel cell carcinoma (MCC) was first used in 1980. [2] MCC is a primary intra-dermal tumor, of neuroendocrine origin, seen mostly in Caucasians above 50 years of age on sun-exposed areas. It is a rare tumor of the skin with a very poor prognosis.

Only a few cases have been reported below 50 years, particularly in immunosuppressed individuals with a possible association with Merkel Cell Polyomavirus, which was first described in 2008 as one of seven known human oncogenic viruses. [3]

MCC commonly presents as a small, less than 2 cm, solid, painless erythematous intradermal mass, usually with no ulceration, and with early nodal metastases. [4],[5]

We report a rare case of MCC in a 33-year-old man who presented with acute bleeding from an ulcerated mass, which was promptly excised with wide local margins. In spite of the relatively aggressive nature of this neoplasm, the patient did not manifest any recurrence over the last 4 years of follow-up.


 > Case report Top


A 33-year-old man presented with a painless, slowly growing mass over the right upper chest wall of 4 months' duration which had spontaneously ulcerated and started bleeding on the day of presentation. There was no recent history of trauma, pain, fever, or weight loss.

On examination, the patient was of average build and nutrition. There was a well-defined, firm, globular, non-tender mass approximately 2 cm in diameter over the right anterior axillary fold. The mass had a smooth surface; it was not fixed to the underlying structures but was fixed to the overlying skin. There was an ulcer at the center of the lesion about 0.5 cm in diameter. The ulcer had rolled-up margins, indurated base, and the floor had adherent clot. There was no clinically apparent regional lymphadenopathy.

Routine and laboratory studies including coagulation profile were unremarkable. Serological tests for HIV were nonreactive. Skiagram of the chest showed no abnormality.

The history and the clinical findings suggested a neoplastic lesion arising from the skin and hence, a wide local excision of the lump with 2 cm margin all around was decided upon promptly. The deeper plane of excision was just superficial to deep fascia. Cut surface was heterogeneous with cystic areas filled with blood.

Histopathology showed a monomorphic appearance with uniform round cells having scanty amphophilic to eosinophilic cytoplasm with vesicular basophilic nuclei with prominent nucleoli, fine granular apoptotic bodies, and mitotic figures in plenty. The lesion was well vascularized and showed areas of hemorrhage [Figure 1].
Figure 1: H and E ×200; showing monomorphic uniform round cells eosinophilic cytoplasm with vesicular basophilic nuclei with prominent nucleoli, apoptotic bodies and mitotic figures

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Immunohistochemistry report showed the tumor to be cytokeratin-20-positive and S100-negative, suggesting it to be MCC.

The patient did not receive any other adjuvant therapy. He is being regularly followed-up for the last 4 years and is doing well so far without any evidence of local or regional recurrence.


 > Discussion Top


MCC is an unusual skin malignancy, which is often confused with amelanotic melanoma. MCC lacks distinctive clinical features, and as such it is difficult to diagnose clinically. By the time the diagnosis is made most of the tumors have metastasized to regional lymph nodes. Differential diagnoses include basal cell carcinoma, lymphoma, melanoma, and squamous cell carcinoma. Aging, sun exposure, and immunosuppression are recognized risk factors. [3] None of these risk factors was present in our patient.

Immunohistochemistry is required to diagnose MCC, as histopathology can only point to malignant round-cell tumor. [6] On histopathology, the triad of vesicular nuclei with small nucleoli, abundant mitosis, and apoptosis is only suggestive of MCC.

On immunohistochemistry, MCC is CK20-positive. It is negative for S100, and this helps in differentiating it from melanoma, metastatic small cell carcinoma of lung, and other round-cell tumors. [6]

Prognosis largely depends on the stage of the disease with 90% 5 years' survival in localized disease. The early presentation of our patient probably explains the absence of nodal metastasis. Presence of lymph node metastases is the most important predictor for survival. [7]

Patients presenting with nodal involvement or clinically evident systemic spread need proper radiological staging.

Surgery is the only curable form of treatment. Wide local excision, Mohs micrographic surgeries are recommended treatment in localized disease. [8]

Therapeutic lymph-node dissection is employed in patients with nodal involvement. Radiotherapy is indicated as an adjuvant therapy in nodal metastases, sometimes in combination with chemotherapy. [9] Chemotherapy primarily is used in metastatic MCC. [7]

In this reported patient, prompt and radical surgery proved to be curative. He was not administered any other adjuvant therapy and there has not been any recurrence, either local or distant, over the last 4 years' follow-up.

 
 > References Top

1.Merkel F. Tastzellen und Tastkörperchen bei den Haustieren und beim Menschen. Arkiv für Mikroskopische Anatomie und Entwicklungsmechanik 1875;11:636-52.  Back to cited text no. 1
    
2.Johannessen JV, Gould VE. Neuroendocrine skin carcinoma associated with calcitonin production: A Merkel cell carcinoma? Hum Pathol 1980;11:586-8.  Back to cited text no. 2
    
3.Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science 2008;319:1096-100.  Back to cited text no. 3
    
4.Yiengpruksawan A, Coit DG, Thaler HT, Urmacher C, Knapper WK. Merkel cell carcinoma. Prognosis and management. Arch Surg 1991;126:1514-9.  Back to cited text no. 4
    
5.Hitchcock CL, Bland KI, Laney RG 3 rd , Franzini D, Harris B, Copeland EM 3 rd . Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment. Ann Surg 1988;207:201-7.  Back to cited text no. 5
    
6.Bobos M, Hytiroglou P, Kostopoulos I, Karkavelas G, Papadimitriou CS. Immunohistochemical distinction between merkel cell carcinoma and small cell carcinoma of the lung. Am J Dermatopathol 2006;28:99-104.  Back to cited text no. 6
    
7.Poulsen M, Rischin D, Walpole E, Harvey J, Mackintosh J, Ainslie J, et al. High-risk Merkel cell carcinoma of the skin treated with synchronous carboplatin/etoposide and radiation: A Trans-Tasman Radiation Oncology Group Study - TROG 96:07. J Clin Oncol 2003;21:4371-6.  Back to cited text no. 7
    
8.Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: Prognosis and treatment of patients from a single institution. J Clin Oncol 2005;23:2300-9.  Back to cited text no. 8
    
9.Veness MJ, Perera L, McCourt J, Shannon J, Hughes TM, Morgan GJ, et al. Merkel cell carcinoma: Improved outcome with adjuvant radiotherapy. ANZ J Surg 2005;75:275-81.  Back to cited text no. 9
    


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