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Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 381-383

Rare presentation of pediatric acute promyelocytic leukemia as multiple lytic bone lesions: Case report and review of literature

1 Department of Pediatric Oncology, Regional Cancer Centre, Trivandrum, Kerala, India
2 Department of Pathology, Regional Cancer Centre, Trivandrum, Kerala, India

Correspondence Address:
Manjusha Nair
PRA 19, Prasanth, Pathirappally Road, Poojappura, Trivandrum - 695 012, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0973-1482.136664

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Acute promyelocytic leukemia (APL) is an uncommon malignancy in the pediatric population, accounting for only 5-10% of pediatric acute myeloid leukemias, and for this disease to present with bone lesions at diagnosis is extremely unusual. We wish to convey that very rarely, in a pediatric cancer patient presenting with multiple extensive lytic bone lesions, the diagnosis can be APL. The treatment protocol and prognostic implications are vastly different. Histopathology is the gold standard in arriving at a correct diagnosis and delivering proper treatment in such cases. This patient had excellent response to chemotherapy.

Abstract in Chinese

儿童急性早幼粒细胞白血病的罕见表现为多个溶骨性病变:病例报告及文献复习 摘要 急性早幼粒细胞白血病(APL)是儿童中常见的恶性肿瘤,只占儿童急性髓细胞性白血病的5%~10%,而这种疾病在诊断时已有骨病变是极罕见的。本文报道一例非常罕见的儿科APL癌症患者有广泛的多发性溶骨性病变,该患者治疗方案和预后完全不同。这类情况下,组织病理学是正确诊断的金标准。这个病人对化疗有很好的反应。 关键词:急性早幼粒细胞白血病,溶骨性病变,儿科

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