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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 354-358

Malignant lymphoma in Eastern India: A retrospective analysis of 455 cases according to World Health Organisation classification


1 Department of Pathology, Medical College, Kolkata, India
2 Department of Radiotherapy, Medical College, Kolkata, India
3 Department of Pathology, Thakurpukur Cancer Hospital, Kolkata, India

Correspondence Address:
Santosh Kumar Mondal
"Teenkanya Complex", Flat 1B, Block B, 204 R N Guha Road, Dumdum, Kolkata - 700028
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136639

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Background: Malignant lymphoma (ML) is one of the most common cancers and is most prevalent in developed countries. The distribution of different subtypes of ML varies in the different geographical locations according to World Health Organization (WHO) classification. Aims and Objectives: The study was aimed to analyze different patterns of ML in Eastern India and to compare it with other geographical locations. Materials and Methods: Four hundred and fifty five patients of two large hospitals in Eastern India were included over a period of four years and were categorized according to WHO classification, using morphology and immunohistochemistry (IHC). Results: There were 347 (76.3%) non Hodgkin lymphomas (NHL), and 108 (23.7%) Hodgkin lymphomas (HL). Diffuse large B cell lymphoma (DLBCL) was the most common of the NHL type (35.2%) followed by the follicular lymphoma (19.3%). B cell lymphoblastic lymphoma was the least common type of NHL (1.4%). Mixed cellularity (33.3%) and nodular sclerosis (26.9%) were the two most common type of HL. Childhood lymphoma comprised of 12.5% of all ML. T cell NHL and HL were the common lymphomas in this age group. Conclusion: Incidence of follicular lymphoma is lower compared to western studies and mixed cellularity is most common subtype of HL unlike nodular sclerosis subtype in western world. Burkitt's type NHL though is the most common subtype of childhood ML in many studies but in our study T cell NHL is the most common type of childhood ML.

Abstract in Chinese

根据世界卫生组织分类标准对455例印度东部的恶性淋巴瘤回顾性分析 摘要 背景:恶性淋巴瘤(ML)是最常见的恶性肿瘤之一,在发达国家是最普遍的。根据世界卫生组织(WHO)的分类,不同亚型的ML分布变化在不同的地理位置。 目的:本研究的目的是分析在印度东部的ML不同的模式,以及它与其他地理性亚型分布比较。 材料与方法:对东印度的两大医院4年间收治的455例患者,利用形态学和免疫组化(IHC)按WHO标准进行分类。 结果:有347例(76.3%)非霍奇金淋巴瘤(NHL),108例(23.7%)霍奇金淋巴瘤(HL)。弥漫性大B细胞淋巴瘤(DLBCL)是最常见的淋巴瘤类型(35.2%)其次是滤泡性淋巴瘤(19.3%)。B细胞淋巴母细胞淋巴瘤的淋巴瘤是最常见的类型(1.4%)。混合细胞型(33.3%)和结节性硬化症(26.9%)是最常见的两种类型的HL。儿童淋巴瘤占所有ML的12.5%。T细胞NHL和HL是在这个年龄组常见的淋巴瘤。 结论:滤泡性淋巴瘤的发病率低于西方的研究,混合细胞型是HL最常见亚型,而西方最常见亚型是结节硬化型。Burkitt型NHL虽然是其它研究中最常见的儿童ML亚型,但在我们的研究中, T细胞NHL是儿童最常见的类型。 关键词:印度东部,淋巴瘤,免疫表型,世界卫生组织



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