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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 342-346

To analyze the impact of intracavitary brachytherapy as boost radiation after external beam radiotherapy in carcinoma of the external auditory canal and middle ear: A retrospective analysis


Department of Radiotherapy, Dr. D K Gosavi Memorial, Siddhivinayak Ganpati Cancer Hospital, Miraj, Maharashtra, India

Correspondence Address:
Dinesh K Badakh
Dr. D K Gosavi Memorial, Siddhivinayak Ganpati Cancer Hospital, Miraj-Sangli Road, Miraj, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136624

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Purpose: The purpose of this study was to analyze the impact of intra-cavitary brachytherapy (ICBT) as boost radiation after external beam radiotherapy (EBRT) in carcinoma of the external auditory canal and middle ear (EACMA): A retrospective analysis. Materials and Methods: A retrospective study of 18 patients with carcinoma of the EACMA who were treated with a curative intent from the year 1998 to 2010 was carried out. The age of the patients ranged from 25 years to 67 years. There were 11 male patients (61.1%) and 7 female patients (38.9%). A total of 15 (88.2%) patients were treated with curative radiation alone after a biopsy and two patients received post-operative radiation therapy. The patients were initially treated with EBRT with cobalt 60 machine up to 60-64 Gy. In our department, all the patients who were technically suitable for ICBT received an ICBT boost. Results: The overall survival (OS) in these patients ranged from 7 months to 151 months (9 out of 17 patients, no evidence of disease 53%). The OS in patients treated with a combination of EBRT with ICBT was (8 out of 11) 72.7%, P value statistically significant (P value: 0.0024). The multivariate analysis shows statistically significant difference only for patients who got an ICBT boost (P Value: 0.020). Conclusion: ICBT as a boost after EBRT has got a positive impact on the OS. In conclusion, our results demonstrate that radical radiation therapy (EBRT and ICBT) is the treatment of choice for stage T2, carcinoma of EACMA.

Abstract in Chinese

回顾性分析外耳道和中耳癌外照射放疗后腔内放疗作为补充放疗的影响 摘要 目的:本研究回顾性分析腔内近距离放射治疗(ICBT)在外耳道和中耳癌(EACMA)中作为外放射治疗(EBRT)的补充放疗的影响。 材料与方法:对1998至2010年间18例EACMA患者进行了一项回顾性研究。患者的年龄介于25岁至67岁。男11例(61.1%),女性7例(38.9%)。总共有15例(88.2%)患者活检后进行单纯放疗,2例接受术后放射治疗。患者最初用钴60机进行外放疗,剂量60~64Gy。所有患者中适用于腔内放疗的均接受了补充腔内放疗。 结果:本研究患者生存时间从7个月到151个月(17例患者中有9例,没有复发的证据,占53%)。外放疗结合腔内放疗的OS为(8/11)72.7%,P值具统计学意义(P值:0.0024)。多因素分析显示仅腔内放疗补充的患者具有统计学显著性差异(P=0.020)。 结论:腔内放疗可作为外放疗的补充,延长患者生存时间,根治性放射治疗(EBRT和ICBT)是T2期EACMA的治疗选择。 关键词:近距离放射治疗,癌,外耳道,中耳,辐射



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