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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 309-311

Micronuclei in breast aspirates. Is scoring them helpful?


Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India

Correspondence Address:
A Hemalatha
Department of Pathology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136588

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Background: Micronuclei scoring can be used as a biomarker of genotoxic and chromosomal damage. Aims: 1. To score the spontaneously occurring micronuclei in the baseline population (fibroadenomas) and infiltrating ductal carcinoma, 2. Compare micronuclei frequency in benign tumors and various grades of infiltrating ductal carcinomas. Materials and Methods: Study was done at a tertiary hospital where 40 cases of fibroadenoma and 40 cases of infiltrating ductal carcinoma were taken up. May Grunwald Giemsa stained smears were analyzed for micronuclei scoring. Statistical Analysis: Independent sample test (Student t test) was done to look for significant difference occurring between the controls among all grades of infiltrating ductal carcinoma. Results: Mean micronuclei range in fibroadenoma was 1.8 ± 1.9. It was 12.1 ± 9.2, 27.4 ± 27.2 and 100 ± 36.5 in grade I, grade II and grade III carcinomas respectively. Conclusion: An increase in micronuclei values was seen from fibroadenoma to infiltrating ductal carcinoma. Micronuclei scoring can be used as a biomarker on fine needle aspiration cytology smears of breast carcinoma.

Abstract in Chinese

乳腺针吸微核评分有益吗? 摘要 背景:微核得分可以作为基因毒性和染色体损伤的生物标志物。 目的:(1)对在基线人口中自然发病的(纤维腺瘤)和浸润性导管癌评分。(2)比较良性肿瘤及各种级别的浸润性导管癌微核率。 材料和方法:研究收集某三级医院40例浸润性导管癌和40例纤维腺瘤患者样本,May Grunwald Giemsa染色涂片并进行微核评分。 统计分析:独立样本检验(t检验)比较所有级别的浸润性导管癌之间的差异。 结果:纤维腺瘤平均微核率范围为1.8±1.9。而在I级、II级、III级癌的得分分别是12.1±9.2,27.4±27.2和100±36.5。 结论:从纤维腺瘤到浸润性导管癌,微核值逐渐增加。微核得分可作为乳腺癌细针穿刺细胞学涂片的生物标志。 关键词:微核,纤维腺瘤,浸润性导管癌,细针穿刺细胞学检查



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