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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 2  |  Page : 244-250

Do tobacco stimulate the production of nitric oxide by up regulation of inducible nitric oxide synthesis in cancer: Immunohistochemical determination of inducible nitric oxide synthesis in oral squamous cell carcinoma - A comparative study in tobacco habituers and non-habituers


Department of Oral Pathology and Microbiology, Coorg Institute of Dental Sciences, Virajpet, India

Correspondence Address:
B Karthik
Department of Oral Pathology and Microbiology, Coorg Institute of Dental Sciences, Virajpet
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.136542

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Background: Oral cancer accounts for 6% of all cancers. The most prevalent form of oral cancer is oral squamous cell carcinoma (OSCC), which accounts for 90% of the oral cancer cases. The major risk factor for development of OSCC is the use of tobacco in various forms. NO has been studied widely over the years due to its role in various physiological and pathophysiological processes, including its complex role in carcinogenesis. Materials and Methods: A total of 20 cases of OSCC in tobacco habituers and tobacco non-habituers were retrieved respectively from the archival biopsy specimens. Immunohistochemistry was done to assess the inducible nitric oxide synthase (iNOS) protein. Results: This study was performed to assess the correlation between tobacco and nitric oxide in OSCC in order to know the association of these two in the process of carcinogenesis. The results showed the enhanced expression of iNOS in tobacco habituers in comparison with tobacco non-habituers. Though the increased expression of iNOS is found, significant difference is not obtained with scores, but significant difference was found with intensity of staining. Conclusions: The results of the present study indicate the enhanced expression in OSCC of tobacco habituers when compared to OSCC of tobacco non-habituers indicating the effect of tobacco on nitric oxide. Carcinogenic chemical compounds in Tobacco induce nitric oxide production by iNOS, by its tumor-promoting effects which may enhance the process of carcinogenesis.

Abstract in Chinese

烟草确是通过上调一氧化氮合酶诱导肿瘤组织一氧化氮产生:比较烟瘾者和非烟瘾者口腔鳞状细胞癌组织中诱导型一氧化氮合酶免疫测定 摘要 背景:所有肿瘤中约6%为口腔肿瘤。口腔肿瘤中最常见的形式为口腔鳞状细胞癌(OSCC),占全部口腔肿瘤中的90%。对口腔鳞癌的发生发展过程中的主要危险因素是各种形式的烟草使用。一氧化氮多年来已经在各种生理和病理过程中的作用进行了广泛的研究,包括其在肿瘤发生中的作用。 材料与方法:收集20例烟瘾者和非烟瘾者的口腔鳞状细胞癌活检标本,免疫组化分析诱导型一氧化氮合酶(iNOS)蛋白表达水平。 结果:本研究旨在评估烟草和一氧化氮在OSCC癌变过程中的相关性。结果表明,烟瘾者较非烟瘾者一氧化氮合酶表达增加,主要体现在染色强度有显著差异。 结论:烟瘾者较非烟瘾者相比,烟草诱导的一氧化氮生成表达增加,推测这与烟瘾者高癌症患病风险相关。 关键词:致癌物质,诱导,口腔鳞状细胞癌,烟草



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