Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 38-42

A single institution retrospective analysis of malignant melanoma


Department of Radiation Oncology, Oncology Hospital of Ankara, Mehmet Akif Ersoy Street, Yenimahalle, 06105, Ankara, Turkey

Correspondence Address:
Aytul Ozgen
Department of Radiation Oncology, Oncology Hospital of Ankara, Mehmet Akif Ersoy Street, Yenimahalle, 06105, Ankara
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131356

Rights and Permissions

Background: The incidence of melanoma is rising at a rate greater than any other malignancy, although much of this increase is due to the more frequent diagnosis of patients with the earlier stages of melanoma. Objective: In this study, patient and tumor-related characteristics and their effects on survival were evaluated. Materials and Methods: The data was drawn from the patients' records with histologically proven primary cutaneous melanomas treated at the Ankara Oncology Hospital between January 2003 and December 2010. Sixty-nine patients (48 men and 21 women) were included in this study. 17 of the patients had already distant metastases at the time of diagnosis. While 45 of all patients had undergone surgery alone, 17 had received only palliative radiotherapy, and 7 had received primary radiotherapy. Survival curves were determined from the time of diagnosis. Results: A total of 69 cutaneous melanoma cases were evaluated. While there was a predominance of males in all body sites, especially in the head and neck regions, the number of male patients was 5 times higher than females. Diseases located on the head tended to present a significantly higher rate in older patients (P = 0.009). Overall survival rates for 1 and 3 years were 79% and 44%, respectively. Distant metastatic melanoma was significantly related with poor prognosis (P < 0.001). Anatomic location showed a borderline significancy as a prognostic factor for overall survival (P = 0.053). Conclusion: Cutaneous melanomas developing at different body sites are associated with distinct patterns of survival outcomes. In this retrospective analysis, melanomas of the head and neck and limb, which are regional melanoma, appear to have better survival outcomes.

Abstract in Chinese

单中心恶性黑色素瘤回顾性分析 背景:恶性黑色素瘤的发病率比其它恶性肿瘤增长显著,虽然此增长多归因于早期恶黑病人的确诊。 目的:本文主要评估病人和肿瘤相关特征及它们对生存期的影响。 材料和方法:数据来源于安卡拉肿瘤医院2003.1~2010.12的组织学证实的原发性皮肤恶性黑色素瘤的病例。包括69病例(48男,21女)。17例在确诊时已有远处转移。45例仅施行手术,17例仅行姑息放疗,7例行根治性放疗。生存曲线从确诊开始计算。 结果:共评估69例皮肤恶黑病例。男性占主导,男性病例数量是女性的5倍,身体任何部位都可发病,尤其在头颈区域。头面部的恶黑在老年病人中显著(P=0.009)。总体1年和3年生存率为79%和44%,另外,远处转移者预后显著差(P<0.001)。解剖学位置在整体生存率提示显明分界线(P=0.053)。 结论:皮肤恶性黑色素瘤发生于不同身体部位提示明显的生存结果差异。本次回顾性分析中,位于头、颈、四肢的区域性黑色素瘤,生存结果优于其它。 关键词:年龄,性别,恶性黑色素瘤,生存期



[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1582    
    Printed77    
    Emailed1    
    PDF Downloaded115    
    Comments [Add]    

Recommend this journal