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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 26-28

Evaluation of ER, PR and HER-2 receptor expression in breast cancer patients presenting to a semi urban cancer centre in Western India


1 Rajarshee Chhatrapati Shahu Maharaj Government Medical College, Kolhapur, India
2 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India
3 Department Of Surgical Oncology, Kolhapur Cancer Centre, Kolhapur, India
4 Department of Preventive and Social Medicine, Rajarshee Chhatrapati Shahu Maharaj Government Medical College, Kolhapur, Maharashtra, India

Correspondence Address:
Suraj B Pawar
Surgical Director, Kolhapur Cancer Centre, Kolhapur - 416 008, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131348

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Background: Hormone receptor expression has been reported to be low in breast cancer patients from developing countries. The pattern of receptor expression from urban and rural areas is not well studied. Materials and Methods: This is a retrospective analysis of 206 consecutive breast cancer patients presenting to a semi urban cancer centre from 2009-2010. The demographic and clinical variables included age, residential area (rural, semi urban, or urban), menopausal status, and clinical stage. The pathological variables included tumor type, the presence of ductal carcinoma in situ, lymphovascular invasion, and expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) receptors by immunohistochemical (IHC) analysis. Results: The majority of patients were postmenopausal with the median age of 50 years. Invasive ductal carcinoma was the most common subtype (94%). The ER status was available in 101 (49.3%), PR in 99 (48.0%), and HER2 in 82 (39.8%) cases. In patients in whom this data were available, ER was positive in 44.6%, PR in 40.4%, and HER2 in 34.2%. Out of the 82 patients in whom data on all three receptors were available, 34.1% patients had triple negative tumors. Analysis of our data showed a trend toward increasing ER and PR expression with age but this was not statistically significant. The average age of menopause was between 40-50 years of age. Conclusion: This report is an important documentation of the pathological characteristics in a predominantly rural/semi urban population of Indian breast cancer patients. Further studies from other centers with a similar background are required to confirm these results.

Abstract in Chinese

印度西部近郊癌症中心乳腺癌患者的ER、PR和HER-2受体表达评估 背景:有报道在发展中国家的乳腺癌患者中激素受体表达处于低水平。来自城市和农村的(患者)受体表达的形式尚未被充分研究。 材料和方法:对2009~2010年位于近郊肿瘤中心收治的206例乳腺癌患者进行回顾性分析。人口统计学和临床变量包括年龄,居住区域(农村、近郊、城市),绝经状态和临床分期。病理学变量包括肿瘤类型,原位癌表达,淋巴转移,雌激素受体(ER),孕激素受体(PR),以及人表皮生长因子受体2(HER-2)表达感受器的免疫组化分析。 结果:入组病人中绝经后患者比例较高,平均年龄50岁。浸润性导管癌是最常见的组织学类型(94%)。ER可测的101例(49.3%),PR 99例(48.0%),HER-2 82例(39.8%)。在这些病人中,ER阳性的占44.6%,RP阳性40.4%,HER-2阳性34.2%。82例三组受体均可测得的病人中,34.1%是三阴乳腺癌。数据分析表明随着年龄增大,ER,PR的表达阳性有增长趋势,但无统计学意义。平均停经年龄是40~50岁。 结论:本文是关于印度乳腺癌患者(主要是农村、半城市人群)的一个病理学特性的重要文献。同时需要源于其它中心的类似背景的进一步研究来证实这些结果。 关键词:乳腺癌,受体,农村的



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