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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 127-132

Alteration of radiation-sensitive processes associated with cancer and longevity by dietary 2-mercaptoethanol


Department of Microbiology, University Minnesota Minneapolis, MN, USA

Correspondence Address:
Robert E Click
N8693 1250 Street River Falls, WI 54022
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131450

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Background: Previous results demonstrated dietary 2-mercaptoethanol (2-ME) delayed appearance of cancer in certain murine strains. In addition, it had a benefit not found with other organosulfurs, in that it completely prevented spontaneous development of cancer in BXSB-Yaa + over an entire lifespan. Aims: These benefits raise the question: What, if any, alteration of radiation-induced tumorigenesis would 2-ME impart that may differ from that of other sulfur antioxidants? This is relevant based on the extensive use of radiation in diagnoses and therapy and 2-ME's superior in vitro and in situ immune enhancement properties. Materials and Methods: This was addressed by exposing long-lived, B10.A (4R) mice to sublethal, 5.5 Gy ionizing gamma-rays and then tumor development monitored over a lifetime. Statistical Analysis: Two-tailed P-values were determined using the Fischer's Exact Test. Results: The only tumors detected were mammary and only in animals that were both exposed to radiation and not treated with 2-ME. The 43% incidence differed significantly from the absence of tumors in non-irradiated mice that were or were not exposed to 2-ME and in those irradiated and treated daily with 2-ME, irrespective of whether treatment was started prior to or post irradiation. However, quite unexpectedly, radiation shortened longevity 29% from undefined causes, including cancer, in animals pretreated with 2-ME; longevity was not altered in those not pretreated or if treatment was started post-irradiation. Conclusions: The findings have relevance for cancer prevention and the controversy relative to ''long term survival/safety'' of currently used antioxidants as free radical scavengers in humans undergoing radiotherapy.

Abstract in Chinese

进食2巯基乙醇导致癌症及长寿相关辐射敏感过程的变更 背景:以前的研究结果表明食用2巯基乙醇(2-ME)延迟在某些小鼠品系癌的出现。此外,它有一个其它有机硫类未发现的好处,因为在BXSB-Yaa+(一种小鼠)整个生命过程中,它完全阻止癌自发发展。 目的:这些好处提出问题:如果有的话,2-ME中有什么物质不同于其他含硫抗氧化剂可以改变辐射诱导的肿瘤发生?这是有关的基础上广泛使用的在诊断、治疗辐射和在体外和原位免疫增强特性的2-ME的优越性。 材料和方法:这是通过长期暴露于亚致死的5.5Gy电离伽马射线的B10.A(4R)小鼠,然后在整个寿命中监测肿瘤的发展。 统计分析:双侧P值均使用Fischer精确检验确定。 结果:唯一检测到的肿瘤是乳腺的,仅在那些暴露于辐射下不经2-ME处理的动物们中。43%的发病率明显不同于非照射小鼠(不论有无2-ME接触)或那些受照射但有每天有2-ME治疗的小鼠,不论治疗开始于照射前或照射后。然而,出乎意料的是,辐射减少了29%寿命,原因不明,包括2-ME预处理但仍生癌的动物们;寿命在那些没有预处理或开始照射后处理的动物中没有改变。 结论:调查结果在肿瘤预防中有实用性,另外关于目前使用的抗氧化剂作为人类放疗中的自由基清道夫的“长期生存/安全”仍有争议。 关键词:2巯基乙醇,抗氧化,癌症辅药,癌症预防,寿命,放射,放射增敏剂



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