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ORIGINAL ARTICLE
Year : 2014  |  Volume : 10  |  Issue : 1  |  Page : 11-14

Role of concurrent chemoradiation in inoperable carcinoma esophagus: A prospective study


Department of Radiation Oncology, Sri Aurobindo Institute of Medical Sciences, Medical College, Indore, Madhya Pradesh, India

Correspondence Address:
Virendra Bhandari
401, Samyak Towers, 16/3 Old Palasia
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.131330

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Introduction: The treatment of choice in cancer esophagus is controversial. Radiation therapy oncology group, Eastern cooperative oncology group and Cochrane studies have shown superiority of concurrent chemoradiation in inoperable carcinoma esophagus. In these studies full dose cisplatin was given every 3 weeks along with radiotherapy and hence had some toxicity. So, we started treating inoperable carcinoma esophagus patients with low dose weekly cisplatin given concurrently with radiotherapy aiming at low toxicity and similar results. Materials and Methods: A total of 31 cases of inoperable cases of carcinoma esophagus were treated with once weekly cisplatin 30 mg/m 2 along with radiotherapy 60 Gy in 30 fractions in 6 weeks on Telecobalt/Linear accelerator. Results : w0 e could achieve lower toxicity with 80%, 35% and 19% with 1, 2, and 3 year's survival with a median survival of 18 months. So, we conclude that this regimen is better than 3 weekly chemotherapy regimen as is better tolerated with less toxicity and similar outcome.

Abstract in Chinese

同步放化疗对不能手术食管癌的前瞻性研究 引言:食管癌的治疗方案选择上是存在争议的。放射治疗肿瘤学组,东部肿瘤协作组和科克伦的研究表明在不能手术食管癌病人中同步放化疗的优越性。在这些研究中,放疗过程中同步给予3周一次足量顺铂,毒副反应较大。本研究拟放疗同步给予每周一次的低剂量顺铂,观察疗效和毒性反应。 材料和方法:入组31例不可手术食管癌病人,予以同步放化疗,放疗:远距离钴治疗加速器治疗,剂量60Gy/30F/6W,化疗:每周30mg/m2顺铂。 结果:1、2、3年生存率分别为80%、35%、19%,中位生存时间18个月,每周方案毒性更低。每周同步低剂量化疗优于3周同步化疗方法,病人承受较少毒性,而治疗效果相似。 关键词:食管癌,同步放化疗,低剂量顺铂



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