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ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 4  |  Page : 587-591

Oral squamous cell carcinomas in age distinct population: A comparison of p53 immunoexpression


1 Department of Oral and Maxillofacial Pathology, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
2 Department of Oral and Maxillofacial Pathology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, India
3 Department of Oral and Maxillofacial Pathology, Mahe Institute of Dental Sciences and Hospital, Palloor, Mahe, Puducherry, India
4 Department of Oral and Maxillofacial Pathology, Dental College, Azamgarh, India
5 Department of Oral and Maxillofacial Pathology, Shree Bankey Bihari Dental College and Research Centre, Ghaziabad, India
6 Department of Conservative Dentistry and Endodontics, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Akhilesh Chandra
2/29 Rashmi Khand, Sharda Nagar, Lucknow - 226 002, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.126452

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Aims: The study aimed to assess the diffused expression of p53 protein in patients with OSCC and its association with age at diagnosis (using 50 years as a cut point). Study Design: Ten normal oral mucosa and sixty OSCC lesions from age-distinct patient populations were immunohistochemically analyzed for the expression of p53 protein. Results: In OSCC cases, 31 out of total 60 cases (51.67%) showed positive expression for p53 protein and it was more common in older study group (56.67%) than in younger study group (46.67%) but the difference was not statistically significant. Moreover, there was also no significant difference in the p53 indices (percentage of p53 positive cells) between the two study groups (P = 0.827). Conclusion: The alteration rates were found to be slightly higher in older patients although not statistically significant.


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