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REVIEW ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 4  |  Page : 583-586

Emphasizing on heat shock protein 90's utility in head and neck squamous cell carcinoma treatment


1 Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bhubaneswar, Odisha, India
2 Department of Periodontics, GITAM Dental College and Hospital, Rushikonda, Vishakhapatnam, Andhra Pradesh, India
3 Department of Oral Pathology and Microbiology,MGM Dental College and Hospital, Kharghar, Navi Mumbai, Maharashtra, India
4 Department of Oral Pathology and Microbiology,Y.M.T. Dental College, Kharghar, Navi Mumbai, Maharashtra, India

Correspondence Address:
Samapika Routray
Department of Oral Pathology and Microbiology, Institute of Dental Sciences, 'SOA' University, Sector 8, Ghatikia, Bhubaneswar, Odisha - 751 003
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.126451

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Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leukemia, castrate refractory prostate cancer, non-small cell lung carcinoma and multiple myeloma using the first generation Hsp90 inhibitors. Hsp90 as the target of anticancer activity of geldanamycin sparked much interest in the inhibition of Hsp90 as a strategy for the treatment of cancer. Hsp90 inhibitors demonstrate rapid clearance from normal tissues and the blood compartment with prolonged retention in tumors making it a sought after modality for treating cancer. Our review emphasizes its role as anti-cancer therapy for head and neck squamous cell carcinoma.


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