Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
REVIEW ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 4  |  Page : 556-563

Sphingosin 1-phosphate contributes in tumor progression


1 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences; Research Center for Pharmaceutical Nanotechnology; Student Research Center Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences; Research Center for Pharmaceutical Nanotechnology; Department of Biochemistry and Clinical Laboratories, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Medical Biotechnology, Faculty of Advanced Medical Sciences; Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
4 Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran
5 Department of Infecious Disease, Tabriz University of Medical Sciences, Tabriz, Iran

Correspondence Address:
Nasser Samadi
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences and Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz
Iran
Login to access the Email id

Source of Support: Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran, Conflict of Interest: None


DOI: 10.4103/0973-1482.126446

Rights and Permissions

Sphingosine-1 phosphate (S1P) is a bioactive lipid that mediates diverse cellular responses. Signaling of S1P is carried out by a family of G-protein coupled receptors (GPCRs), which show differential expression patterns depending on tissue and cell types. Activation of S1P receptors induces signaling pathway, which can subsequently lead to physiological process. Intercellular S1P concentration is regulated and determined by several enzymes including S1P lyase, S1P kinase and S1P phosphatase. Numerous studies showed the role of S1P in malignant behavior of cancer cells including breast, lung, colon, and leukemia cell lines. In the past decade, extensive research activities have focused on elucidating S1P signaling pathway, its receptors, enzymes involved in S1P metabolism, and its performance in cancer biology. In this review, we will explain the function of S1P in tumor progression that demonstrated in past research articles and we will express its importance as a target for designing futuristic anticancer drug.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4404    
    Printed101    
    Emailed2    
    PDF Downloaded276    
    Comments [Add]    
    Cited by others 1    

Recommend this journal