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ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 2  |  Page : 250-252

The expression of Heparanase mRNA and its clinical significance in Hepatocellular carcinoma


Department of General Surgery, Jiangsu Shengze Hospital, Wujiang, Jiangsu, China

Correspondence Address:
Yu Shen
Department of General Surgery, Jiangsu Shengze Hospital, 9 Shichangzhonglu Road, Wujiang, Jiangsu
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.113377

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Objective: To investigate the clinico-pathologic importance of Heparanase mRNA expression in hepatocellular carcinoma and its relationship with prognosis. Materials and Methods: Fresh tumors and noncancerous liver tissues were obtained from 30 hepatocellular carcinoma patients after hepatectomy. Expression levels of Heparanase and glyceraldehyde-3-phosphate dehydrogenase mRNA were quantitatively analyzed by real-time reverse transcriptase-polymerase chain reaction. Results: The relative Heparanase mRNA expression level (Heparanase: glyceraldehyde-3-phosphate dehydrogenase ratio) in hepatocellular carcinoma was lower than that in noncancerous tissue (P < 0.05). Conclusion: Reduced Heparanase mRNA expression might result in abnormal cell growth and correlate with hepatocellular carcinoma progression.


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