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ORIGINAL ARTICLE
Year : 2013  |  Volume : 9  |  Issue : 1  |  Page : 17-21

Image-guided intensity-modulated whole abdominal radiation therapy in relapsed epithelial ovarian cancers: A feasibility study


1 Department of Radiation Oncology, Tata Memorial Centre, Mumbai, India
2 Department of Medical Oncology, Tata Memorial Centre, Mumbai, India
3 Department of Gynecologic Oncology, Tata Memorial Centre, Mumbai, India

Correspondence Address:
Umesh Mahant Shetty
Department of Radiation Oncology, Tata Memorial Centre, Dr. E. Borges Marg, Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.110343

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Background and Purpose: Advanced epithelial ovarian cancer is associated with high relapse rates. Various consolidative therapies, including whole abdominal radiationtherapy (WAR), have been tried in the past with limited success. We report here a feasibility study and clinical outcome of WAR with helical tomotherapy (HT). Materials and Methods: Eight patients with relapsed carcinoma ovary after standard treatment and deemed not suitable for further chemotherapy were treated with WAR using HT. All patients underwent intensity-modulated radiotherapy (IMRT) planning process and a dose of 25Gy/25#, at 1Gy/# to the whole of the abdomen [abdominal planning treatment volume (PTV)] with a simultaneous boost of 45Gy/25#, at 1.8Gy/# to the pelvic PTV was prescribed. Results: There was an excellent coverage in both abdominal and pelvic PTVs.The V 95% (volume covered by the 95% isodose) and V 107% (volume receiving 107% dose) was 95.6 (±2.7)% and 2.6 (±0.5)% for abdominal PTV and 95.7 (±2.4)% and 0% for pelvic PTV, respectively. With a median follow-up of 15 months (10-24 months, mean: 14 months), 3patients developed disease recurrence. All 3recurred in the peritoneum, one progressed to intestinal obstruction and fatal septicemia. Conclusion: WAR in recurrent/relapsed epithelial ovarian cancer is feasible with acceptable toxicities.


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