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REVIEW ARTICLE
Year : 2012  |  Volume : 8  |  Issue : 2  |  Page : 176-183

The pleiotropic effects and therapeutic potential of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in malignancies: A comprehensive review


1 Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA
2 Columbia University Division of Cardiology at Mount Sinai Heart Institute, Miami Beach, Florida, USA

Correspondence Address:
Orlando Santana
Echocardiography Laboratory Mount Sinai Heart Institute 4300 Alton Road Miami Beach, Florida 33140
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.98967

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The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes via actions known as pleiotropic effects. Our paper serves as a focused review of pre-clinical investigations and published clinical data regarding the pleiotropic effects of statins in malignancies and emphasizes the importance of randomized, placebo-controlled trials to further elucidate this interesting phenomenon.


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