| REVIEW ARTICLE |
|
| Year : 2012 | Volume
: 8
| Issue : 2 | Page : 176-183 |
The pleiotropic effects and therapeutic potential of the hydroxy-methyl-glutaryl-CoA reductase inhibitors in malignancies: A comprehensive review
Simon Zeichner1, Christos G Mihos2, Orlando Santana1
1 Department of Internal Medicine, Mount Sinai Medical Center, Miami Beach, Florida, USA
2 Columbia University Division of Cardiology at Mount Sinai Heart Institute, Miami Beach, Florida, USA
Correspondence Address:
Orlando Santana
Echocardiography Laboratory Mount Sinai Heart Institute 4300 Alton Road Miami Beach, Florida 33140
USA
DOI: 10.4103/0973-1482.98967
The hydroxy-methyl-glutaryl-CoA reductase inhibitors (statins) are used extensively in the treatment of hyperlipidemia. They have also demonstrated a benefit in a variety of other disease processes via actions known as pleiotropic effects. Our paper serves as a focused review of pre-clinical investigations and published clinical data regarding the pleiotropic effects of statins in malignancies and emphasizes the importance of randomized, placebo-controlled trials to further elucidate this interesting phenomenon.
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