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Year : 2012  |  Volume : 8  |  Issue : 1  |  Page : 62-67

Bone marrow involvement by lymphoproliferative disorders after renal transplantation: PTLD. Int. Survey

1 Department of Medicine, Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Department of Medicine, International Travel Medicine Center of Iran, Tehran, Iran
3 Department of Medicine, Dr. Taheri Medical Research Group, Tehran, Iran

Correspondence Address:
Seyed Hasan Saadat
The Health Research Center; Deputy of Research, Headquarters' building, Baqiyatallah University of Medical Sciences, Mollasadrast, Vanaksq, Tehran
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Source of Support: Baqiyatallah University of Medical Sciences, Conflict of Interest: None

DOI: 10.4103/0973-1482.95176

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Context: Renal graft recipients who develop post-transplant lymphoproliferative disorders (PTLD) that complicate bone marrow (BM). Aims: To investigate features, predictors and prognosis of BM involvement by PTLD in renal transplant patients. Settings and Design: A comprehensive search for the available data though PubMed and Google Scholar for reports of PTLD localization in BM in renal allograft recipients. Materials and Methods: Data of 168 PTLD cases in renal transplant context who have developed bone marrow PTLD gathered from 18 studies and were pooled and analyzed. Statistical Analysis Used: Chi-square test, Student's t test and fissure's exact test were employed. Results: Chi-square test showed that renal recipients with BM PTLD were significantly more likely to represent multi-organ disease (P<0.001), and disseminated PTLD (P<0.001). BM PTLD was also more frequently seen among pediatric renal recipients who had developed PTLD (P=0.016). PTLD, in BM PTLD renal recipients more significantly complicated liver (P=0.008), but less commonly affected skin (P=0.045). BM PTLD lesions were relatively more likely to be of monomorph phenomenon (P=0.06). Conclusions: Renal recipients with BM PTLD represent worse outcome and more unfavorable histopathological phenomenon than in other organ involvements. Moreover, a concomitant PTLD involvement site in liver was found which necessitates full hepatic evaluation for a potential complication by the disease in renal recipients whose BM is involved.

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