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ORIGINAL ARTICLE
Year : 2011  |  Volume : 7  |  Issue : 3  |  Page : 286-291

Study of the cytogenetic and non-cytogenetic factors in cervical carcinoma in the Jammu region of J and K state


1 Institute of Human Genetics, University of Jammu, Jammu and Kashmir, India
2 Department of Gynecology and Obstetrics, SMGS Hospital, Jammu and Kashmir, India

Correspondence Address:
Subash Gupta
Centre Coordinator, Institute of Human Genetics, University of Jammu, Jammu and Kashmir - 180 006
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.87019

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Aim: The present study was aimed to analyze the chromosomal changes and also to work out the association of some of the non-cytogenetic factors in the confirmed cases of cervical carcinoma. Materials and Methods: Slides for the chromosome study were prepared from the tumor growths of 78 patients as the diagnosed cases of cervical carcinoma. The slides so prepared were then subjected to G-banding to rule the involvement of different chromosomes in the progression of cervical cancer. Non-cytogenetic factors that are considered to be the risk factors for CaCx were also taken up during the present study to study the etiology of cervical cancer. Results: Both the numerical and the structural chromosomal changes have been recorded in a majority of these growths. In most of the cases, numerical chromosomal changes (95%) outnumbered the structural aberrations. Discussion: Aneuploidy was the most common numerical chromosomal aberration recorded in the majority of the tumor growths. Structural aberrations included translocations and deletions. Non-cytogenetic factors like multiparity, early marriage, poor genital hygiene and rural background were highly prevalent in the present study.


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