Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2011  |  Volume : 7  |  Issue : 2  |  Page : 143-147

Quantitative evaluation of serum fucose in oral squamous cell carcinoma patients


1 Department of Oral and Maxillofacial Pathology, Modern Dental College, Indore, India
2 Department of Periodontics, Modern Dental College, Indore, India

Correspondence Address:
Rajkumar N Parwani
Department of Oral and Maxillofacial Pathology, Modern Dental College, Indore
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.82928

Rights and Permissions

Background: Cancer, a disorder of cellular behavior is characterized by the alteration of serum glycoproteins, which are composed of different monosaccharides. One of the monosaccharides is l-fucose, a methyl pentose, which is the terminal sugar in most of the plasma glycoproteins. Elevated levels of protein-bound fucose have been reported in various disease states as well as in malignancies. Aim: To ascertain the role of serum fucose as a biomarker and to correlate with other studies for its effective clinical application. Materials and Method: T0 he study was carried out on 67 subjects, including 14 healthy individuals and 53 oral squamous cell carcinoma cases. The serum fucose level estimation was done based on the method as adopted by Winzler using cysteine reagent. Statistical analysis included Chi-square test, Karl Pearson correlation test and Student's t test to evaluate the significance and variability of values between groups. Results: Serum fucose levels were independent of age and sex. However, there was significant increase in mean serum fucose level of oral squamous cell carcinoma patients compared with healthy controls. The results correlated well with other studies. Conclusion: Serum fucose can be used as an effective diagnostic biomarker in oral squamous cell carcinoma patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed4043    
    Printed180    
    Emailed3    
    PDF Downloaded399    
    Comments [Add]    
    Cited by others 2    

Recommend this journal