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LETTER TO THE EDITOR
Year : 2010  |  Volume : 6  |  Issue : 4  |  Page : 588-590

Ameloblastoma mimicking as mucoepidermoid carcinoma on cytology


Department of Pathology, University College of Medical Sciences, Delhi, India

Date of Web Publication24-Feb-2011

Correspondence Address:
Sonal Sharma
Department of Pathology, University College of Medical Sciences, Shahdara, Delhi-110095
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.77093

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How to cite this article:
Makhija M, Sharma S, Kotru M. Ameloblastoma mimicking as mucoepidermoid carcinoma on cytology. J Can Res Ther 2010;6:588-90

How to cite this URL:
Makhija M, Sharma S, Kotru M. Ameloblastoma mimicking as mucoepidermoid carcinoma on cytology. J Can Res Ther [serial online] 2010 [cited 2020 Jul 9];6:588-90. Available from: http://www.cancerjournal.net/text.asp?2010/6/4/588/77093

Sir,

A mass in the salivary gland region often presents a diagnostic challenge with regard to its site of origin (salivary versus non-salivary), benign or malignant nature, and tissue-specific diagnosis.

A 30-year-old female presented with a painless left submandibular swelling. The patient gave a history of surgery eight years back in the same region. Previous surgical notes and histopathology sections could not be procured for a review. On examination a submandibular swelling was seen measuring 4×3 cm.

The smears were hypercellular and showed a mucoid background with debris. There were tight clusters and sheets of hyperchromatic epithelial cells [Figure 1]. Keratinized squamous cells were seen among cells with intercellular cytoplasmic vacuoles containing mucin which stained metachromatically with MGG [Figure 2]. Mitotic figures were absent. On the basis of these cytomorphorphological features from a submandibular swelling with history of previous surgery, a diagnosis of recurrent mucoepidermoid carcinoma was considered.
Figure 1: Pap stained smear showed tight clusters of cells. (Pap, ×100)

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Figure 2: Intracytoplasmic vacuoles (MGG, ×200)

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Subsequent excision of the mass was carried out. Cut section was nodular and showed mucoid material oozing from the cut surface. Sections showed a circumscribed soft tissue tumor mass consisting of nests and aggregates of basaloid cells showing peripheral palisading and squamous metaplasia. A loose meshwork of stellate reticulum was seen in the center [Figure 3]. On the basis of classical histopathological findings a diagnosis of ameloblastoma was suggested.
Figure 3: Histological sections nests with palisaded basaloid cells with central reticulum cells and squamous metaplasia (H and E, Low magnification)

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Radiological review showed that a part of the mandible had been removed as a part of previous surgery. The post-operative course of the patient was uneventful. The patient was followed up for six months and is doing well.

Ameloblastoma is the most frequent epithelial odontogenic neoplasms constituting about 1% of jaw tumors. [1] Ameloblastoma has invasive property and a tendency for local recurrence.

The differential diagnosis of ameloblastoma on cytology includes mucoepidermoid carcinoma, adenoid cystic carcinoma, odontogenic tumors, myxomas, giant cell lesions and pilomatrixoma. In our case the presence of mucoid background, mucin vacuoles and squamous cells misled the diagnosis of mucoepidermoid carcinoma. Choudhary et al. also agree that cellular qualities of ameloblastoma may superficially resemble intraosseous salivary gland neoplasms among other odontogenic cysts. [2] And since in our case the lesion presented as a soft tissue mass a differential of a more common salivary tumor was offered initially. However on retrospect, it was noticed that these squamous cells did not show any nuclear pleomorphism. These anatomizing squamous cells actually constitute the stellate reticulum like component of ameloblastoma. The large, polygonal, distinct cytoplasm of these cells is described as basophilic and contains occasional small vacuoles. Moreover ameloblastomas with cystic change may provide samples with myxoid background material, abundant macrophages and leukocytes without lesional cells indicative of cystic degeneration. [3]

However, the presence of peripheral palisading, presence of spindle cells and the lack of nuclear pleomorphism in squamous cells should lead to the correct diagnosis of ameloblastoma. Ameloblastomas have sufficiently distinctive cytologic features to make the diagnosis by FNAC possible.

 
 > References Top

1.Mathew S, Karen R, Ali SZ, Busseniers AE, Rosenthal DL. Ameloblastoma. Cytologic findings and literature Review. Acta Cytol 1997;41:955-60.  Back to cited text no. 1
    
2.Choudhary M, Dhar S, Bajaj P. Primary diagnosis of Ameloblastoma by fine needle aspiration: A report of two cases. Diag Cytopathol 2000;23:414-6.  Back to cited text no. 2
    
3.Günhan O. Fine needle aspiration cytology of Ameloblastoma. A report of ten cases. Acta Cytol 1996;40:967-9.  Back to cited text no. 3
    


    Figures

  [Figure 1], [Figure 2], [Figure 3]



 

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