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REVIEW ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 9  |  Page : 36-40

Different ways to improve the clinical effectiveness of radioimmunotherapy in solid tumors


Cancer Research Department, Inserm, Universite de Nantes, U601, Nantes, France

Correspondence Address:
Jean-Francois Chatal
GIP Arronax, 1, rue Aronnax, Nantes-Saint-Herblain 44818
France
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.55139

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Radioimmunotherapy (RIT) has been proven effective in the treatment of radiosensitive non-Hodgkin lymphoma but, for radioresistant solid tumors, new approaches are necessary to improve the clinical effectiveness. A real improvement has been the introduction of the pretargeting technology which appeared to be able to significantly increase tumor-to-normal organ uptake ratios.Another very promising approach consists in associating RIT with other treatment modalities. Finally the use of alpha particle-emitting radionuclides such as astatin-211 or bismuth-213 (alpha-RIT) should allow to efficiently eradicate disseminated microscopic clusters of tumor cells or isolated tumor cells which fit well with the short path length of alpha particles.


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