Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents  
CASE REPORT
Year : 2009  |  Volume : 5  |  Issue : 3  |  Page : 203-205

Epitrochlear lymph node metastases from invasive ductal breast cancer


1 Department of Radiotherapy, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014, India
2 Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
3 Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014, India

Date of Web Publication16-Oct-2009

Correspondence Address:
Pavan Kumar
Department of Radiotherapy, Regional Cancer Centre, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow - 226 014
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.57127

Rights and Permissions
 > Abstract 

Metastasis to an epitrochlear lymph node from a primary invasive breast cancer has not been reported earlier. We report a case of epitrochlear lymph node metastasis that presented 10 years after the primary breast malignancy had been treated with radiotherapy, chemotherapy, and hormonal therapy. The patient was successfully treated and continues to remain asymptomatic more than 2 years after she presented with the metastasis.

Keywords: Epitrochlear lymph node, invasive breast carcinoma, metastases


How to cite this article:
Kumar P, Singh S, Datta N R, Tandon A. Epitrochlear lymph node metastases from invasive ductal breast cancer. J Can Res Ther 2009;5:203-5

How to cite this URL:
Kumar P, Singh S, Datta N R, Tandon A. Epitrochlear lymph node metastases from invasive ductal breast cancer. J Can Res Ther [serial online] 2009 [cited 2019 Nov 22];5:203-5. Available from: http://www.cancerjournal.net/text.asp?2009/5/3/203/57127


 > Introduction Top


Breast cancer most frequently metastasizes to bone, lung, liver, brain, and skin. Dissemination to other sites like spleen, [1] gall bladder, [2] eye, [3] urinary bladder, [4] and submaxillary gland, [5] have also been reported but are unusual. We report a case of invasive ductal breast cancer with metastasis to an unusual site: the epitrochlear lymph node. This patient presented 10 years after treatment of the primary tumor. To the best of our knowledge such a case has not been reported earlier in the literature.


 > Case Report Top


A 51-year-old postmenopausal lady presented in November 1995 as a case of cancer right breast, which was staged pT 1 N 1 M 0 after modified radical mastectomy. Histopathology showed invasive ductal carcinoma, with three out of the six dissected axillary lymph nodes having metastatic disease along with evidence of vascular emboli. Her metastatic workup, which included skiagram of the chest and bone and liver scans, was normal. She had a past history of subtotal thyroidectomy in 1993 and was on thyroxin replacement therapy. She received postoperative locoregional radiotherapy to a total dose of 50 Gy in 25 fractions delivered over 5 weeks. Radiotherapy was completed in January 1996. This was followed by six cycles of adjuvant chemotherapy, consisting of cyclophosphomide (500 mg/m 2 ), methotrexate (50 mg/m 2 ), and 5-fluorouracil (500 mg/m 2 ), administered parenterally on days 1 and 8 of a 4-weekly cycle. Chemotherapy was completed in June 1996. She was thereafter put on hormonal therapy (tamoxifen 10 mg twice daily) for 5 years till August 2001.

The patient was on regular follow-up. She had yearly metastatic workup and was asymptomatic till October 2005, when she complained of a swelling in the right elbow region. On examination, there was a mobile 3.0 Χ 1.5 cm nodal swelling in the medial side of the right elbow in the epitrochlear region. There was no past history of any skin lesion, and no pigmented cutaneous lesion or ulceration of the skin was seen on clinical examination. Inspection of the entire skin and mucosal surfaces, as well as detailed examination of the area drained by the affected lymphatic basin, was within normal limits. Fine needle aspiration cytology showed paucicellular smears, mainly composed of scattered single and loosely cohesive neoplastic cells, with occasional acinar structures. The cells were large, with a high nuclear-cytoplasmic ratio, hyperchromatic nuclei, and scant to moderate cytoplasm, and were seen against a hemorrhagic background with sparse lymphoid cells. Against the background of the patient's past history of carcinoma of the breast, these features were suggestive of metastatic ductal carcinoma deposits in an epitrochlear lymph node [Figure 1]. The metastatic workup was otherwise normal.

She refused surgical excision of the node and was therefore treated with palliative radiotherapy to the right epitrochlear region to a total dose of 36 Gy delivered in 12 fractions. There was complete regression of the epitrochlear node following completion of radiotherapy in December 2005. She was resumed on tamoxifen 10 mg twice daily for 2 years, which was changed to letrozole 2.5 mg once daily from February 2008 onwards. On follow-up, the metastatic workup has been normal and the patient continues to be asymptomatic.


 > Discussion Top


Metastases from invasive ductal carcinoma of the breast usually involve bone, liver, lung, and brain. To the best of our knowledge, and according to the literature, involvement of epitrochlear node has never been reported. This is perhaps the first case report of epitrochlear lymph node metastasis from a neoplastic lesion of the breast.

Benign lymphadenopathy of the epitrochlear lymph node has been suggested to result from minor trauma and infection caused by the fungus Sporothrix schenckii in gardeners or by the bacterium Bartonella henselae in cat-scratch disease. [6] Malignant etiology includes mainly lymphoma and chronic lymphocytic leukemia, but these malignancies are likely to cause generalized lymphadenopathy.

Ratanatharathorn et al. reported a series of 32 patients with primary carcinoma of the breast and metastasis to the eye. The time interval from diagnosis of the primary lesion to detection of the metastasis ranged from 2 to 107 months, with a median interval of 56 months. [7] Smet et al. reported a case in which metastases to the index metacarpal was seen 11 years after mastectomy had been done for the primary breast tumor. The metastasis appeared late and progressed slowly; the patient survived for 4 years after the metastasis was diagnosed. [8]

Chambers and her colleagues observed that most cancer cells that enter the circulation generally stop at the first tangle of capillaries they encounter, apparently because the vessels simply become too small for the cells to pass through. The cancer cells either die or fail to grow in their new locations. An ability of these cells to lie dormant may explain why some breast cancer metastases show up as late as two decades after surgery and/or other treatment has been carried out to eradicate the primary neoplasm. Of the cells that do grow, few divide often enough to produce clinically relevant metastases. [9]

Once individual tumor cells arrive at the secondary site, they may experience one of three fates: they may proliferate to form micrometastases, they may die, or they may remain viable but dormant. These dormant solitary cells are defined by a prolonged state of G 0 , where there is an absence of either proliferation or apoptosis. This quiescence is likely to afford protection from many conventional cytotoxic drugs, which only target actively cycling cells. If these solitary cancer cells do begin to proliferate and go on to form micrometastases, they may again experience one of three fates at this next stage: they may continue to proliferate to form vascularized macrometastases, they may die, or they may persist as 'dormant' micrometastases. Dormancy at this stage would mean a balance between cell proliferation and apoptosis within the cell population, such that there is no net increase in the size of the micrometastases. [10]

In the present case, right epitrochlear lymph node metastases occurred 10 years after treatment of the primary right breast cancer. The theory outlined above can very well explain this long time gap since the primary histopathology report had mentioned the presence of vascular emboli.

Smith et al. reported epitrochlear lymph node metastases in 18% (7/39) of patients with cutaneous melanoma of the forearm and hand when the lesion was within 5 cm of the elbow or was on the ulnar aspect. [11] Armando et al. have reported that 5.6% of cases of metastatic malignant melanoma to lymph nodes show no obvious detectable primary. However, the most commonly accepted explanation for an unknown primary in metastatic melanoma is spontaneous regression of the primary cutaneous lesion. [12] This possibility was also ruled out in our patient since she had no past history of a skin lesion.

The prolonged survival achieved after her salvage treatment consisting of radiation therapy indicates that radiotherapy can give quick and effective disease control at this site. This patient continues to be on close follow-up so that any new metastases can be identified as early as possible.

To summarize, in this case report, we describe a novel metastatic site in cancer breast that has not been reported so far and also describe its successful control.

 
 > References Top

1.Barreca M, Angelini D, Gallo A, Puntillo F, Amodio PM, Fernandes E. Single asymptomatic splenic metastasis of breast carcinoma: Report of a clinical case. G Chir 2001;22:227-8.  Back to cited text no. 1
[PUBMED]    
2.Calafat P, de Diller AB, Sanchez C. Breast carcinoma metastasis in ileum-colon and gallbladder simulating inflammatory diseases. Rev Fac Cien Med Univ Nac Cordoba 1999;56:123-7.  Back to cited text no. 2
[PUBMED]    
3.Po SM, Custer PL, Smith ME. Bilateral lagophthalmos. An unusual presentation of metastatic breast carcinoma. Arch Ophthalmol 1996;114:1139-41.  Back to cited text no. 3
    
4.Silverstein LI, Plaine L, Davis JE, Kabakow B. Breast carcinoma metastatic to bladder. Urology 1987;29:544-7.  Back to cited text no. 4
[PUBMED]    
5.Rosti G, Callea A, Merendi R, Beccati D, Tienghi A, Turci D, et al. Metastases to the submaxillary gland from breast cancer: case report. Tumori 1987;73:413-6.  Back to cited text no. 5
[PUBMED]    
6.Bernard M. Karnath. Review of Clinical Sign, Approach to the patient with lymphadenopathy. www.turner-white.com, Hospital Physician July 2005; 29-33.  Back to cited text no. 6
    
7.Ratanatharathorn V, Powers WE, Grimm J, Steverson N, Han I, Ahmad K, et al. Eye metastases from carcinoma of the breast: diagnosis, radiation treatment and results. Cancer Treat Rev 1991;18:261-76.  Back to cited text no. 7
[PUBMED]  [FULLTEXT]  
8.De Smet L. Late appearance and slow progression of a breast carcinoma metastasis of the index metacarpal. Acta Chir Belg 2004;104:345-6.   Back to cited text no. 8
[PUBMED]    
9.Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002;2:563-72.  Back to cited text no. 9
[PUBMED]  [FULLTEXT]  
10.Allan AL, Vantyghem SA, Tuck AB, Chambers AF. Tumor dormancy and cancer stem cells: implications for the biology and treatment of breast cancer metastasis. Breast Disease 2006-2007; 26:87-98.  Back to cited text no. 10
    
11.Smith TJ, Sloan GM, Baker AR. Epitrochlear node involvement in melanoma of the upper extremity.Cancer 1983;51:756-60.   Back to cited text no. 11
[PUBMED]    
12.Giuliano AE, Moseley HS, Morton DL. Clinical aspects of unknown primary melanoma. Ann Surg 1980;191:98-104.  Back to cited text no. 12
[PUBMED]  [FULLTEXT]  


    Figures

  [Figure 1]



 

Top
 
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

  >Abstract>Introduction>Case Report>Discussion>Article Figures
  In this article
>References

 Article Access Statistics
    Viewed7766    
    Printed138    
    Emailed0    
    PDF Downloaded314    
    Comments [Add]    

Recommend this journal


[TAG2]
[TAG3]
[TAG4]