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ORIGINAL ARTICLE
Year : 2009  |  Volume : 5  |  Issue : 3  |  Page : 165-172

Preliminary results of SIB-IMRT in head and neck cancers: Report from a regional cancer center in northern India


Department of Radiotherapy and Oncology, Regional Cancer Center, PGIMER, Chandigarh, Chandigarh UT, India

Correspondence Address:
Santam Chakraborty
Department of Radiotherapy and Oncology, Regional Cancer Center, Post Graduate Institute of Medical Education and Research, Chandigarh - 160 012, Chandigarh UT
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.57121

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Background : Intensity-modulated radiotherapy using simultaneous integrated boost (SIB-IMRT) is an attractive method for the treatment of head and neck cancers with sparing of the salivary function. Aims : To assess the feasibility, toxicity, and tumor control using SIB-IMRT in locally advanced head and neck cancers in the Indian setting. Settings and Design : The study was conducted in a regional cancer center in northern India. A review of the treatment result of the first 20 patients is presented. Methods and Materials : SIB-IMRT was planned for 20 patients-14 patients were treated with the SIB-72 schedule delivering a dose of 72 Gy, 66 Gy, and 57 Gy to the PTV GTV , PTV CTV1 , and PTV CTV2 in 33 fractions. Six patients were treated with the SIB-66 schedule delivering 66 Gy, 60 Gy, and 54 Gy to the above-mentioned volumes in 30 fractions. Patients were monitored for toxicity using the CTCAE v 3.0 criteria. Descriptive analysis of toxicity and actuarial estimates of the loco-regional control and survival are presented. Results : Grade III mucositis was seen in 65% patients. None of the patients had Grade III dermatitis. The projected 2-year overall survival was 95%. Conclusion : SIB-IMRT schedules evaluated were found to be safe and effective and are being subjected to further prospective studies.


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