Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2008  |  Volume : 4  |  Issue : 2  |  Page : 57-59

Utility of blood DNA levels in diagnosis of breast cancer


1 Department of Biochemistry and Biophysics, St. Johnís Medical College, Bangalore, Karnataka, India
2 Department of Biochemistry, M.S.Ramaiah Medical College, Bangalore, Karnataka, India

Correspondence Address:
C R Wilma Delphine Silvia
Department of Biochemistry, M.S. Ramaiah Medical College, MSR Nagar, Bangalore - 54, Karnataka
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.40826

Rights and Permissions

Background: Prognostic factors, including both histopathological and biochemical variables, influence the choice of modality and the course of therapy in breast cancer. The biomarkers found in biological fluids, particularly in blood, apparently hold the best promise for the development of screening assays. Aim: To find out if any correlation exists between blood DNA level and tumor stage, size and grade. Materials and Methods: This case-control study was carried out on 52 female patients in the age-group of 18-70 years. The cases comprised 25 patients with histopathologically confirmed malignant breast cancer, while 27 patients with benign breast tumors served as the control group. Statistical Analysis: We used the Student's 't' test to compare the differences between the blood DNA levels in the two groups. Pearson's test was performed to find out the correlation between blood DNA levels and the TNM stage, tumor size and grade Results: It was observed that blood DNA levels showed statistically significant correlation with the TNM stage, tumor size and grade. Conclusion: The blood DNA level can be utilized as a noninvasive marker to assess tumor aggressiveness. Thus, it can be useful as a prognostic marker and as a marker of tumor burden.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed5543    
    Printed235    
    Emailed2    
    PDF Downloaded362    
    Comments [Add]    
    Cited by others 1    

Recommend this journal