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BRIEF COMMUNICATION
Year : 2007  |  Volume : 3  |  Issue : 3  |  Page : 167-168

Serum total glutathione-s-transferase levels in oral cancer


Department of Biochemistry, Kasturba Medical College, Manipal - 576 104, Karnataka, India

Correspondence Address:
Krishnananda Prabhu
Department of Biochemistry, Kasturba Medical College, Manipal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.37411

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We conducted a study wherein serum total glutathione-s-transferase levels were measured in patients (n = 27) with various stages of biopsy proven oral cancer (squamous cell carcinoma) and age and sex matched healthy human volunteers (n=10). In all patients with oral cancer, serum total glutathione-s-transferase was measured before the onset of treatment. There was a significant increase in serum total glutathione-s-transferse levels in patients with stage IV oral cancer as compared to stage II (P = 0.001) and stage III (P = 0.002) oral cancer. This shows that alterations in serum total Glutathione-s-transferase levels may have a role in cancer progression.


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