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REVIEW ARTICLE
Year : 2007  |  Volume : 3  |  Issue : 3  |  Page : 157-165

Brain metastases from breast cancer:Management approach


1 Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India
2 Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India

Correspondence Address:
Sudeep Gupta
Department of Medical Oncology, Tata Memorial Hospital, Mumbai - 400 012
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.37409

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Brain metastases are a significant cause of morbidity and mortality in patients with breast cancer. HER-2 positivity is an increasingly recognized risk factor for the development of brain metastases. Although considerable progress has been made in the treatment of this complication, supportive measures like steroids, anti-seizure medication and whole-brain radiation remain the cornerstones of management in the majority of patients. The current review discusses the above and other issues like surgical excision, stereotactic radiotherapy, adjuvant radiation, radiosensitization and chemotherapy. A brief discussion of the recent evidence for the use of 'HER-1/ HER-2'-targeted therapy is also present.


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