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ORIGINAL ARTICLE
Year : 2005  |  Volume : 1  |  Issue : 1  |  Page : 38-40

A phase I trial of tocoferol monoglucoside in patients undergoing hemi-body radiation


1 Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai, India
2 Radiation Biochemistry Section, Radiation Biology and Health Science Division, BARC, Anushaktinagar, Mumbai, India
3 Kinki Invention Center, Yoshida Kawahara.cho 14, Sakyo-ku, Kyoyo - 606 8305, Japan

Correspondence Address:
N G Huilgol
Division of Radiation Oncology, Nanavati Hospital, Vile Parle (W), Mumbai
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0973-1482.16089

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Purpose: To evaluate Tocoferol monoglucoside (TMG), a water soluble vit. E. in a phase I trial, as a radiation protector in those undergoing hemi-body radiation for disseminated disease. Materials and Methods: Patients scheduled to receive modified hemi-body radiation were accrued for the study. Patients not only had disseminated skeletal disease but, were heavily pretreated Seven patients were accrued for the study. Patients received 1 and 2 gms of TMG. 30-40 minutes before hemibody radiation. A dose of 600 cGy was delivered on telecobalt equipment at mid plane. Immediate Toxicities were evaluated as well as response to pain. Results: All the seven patients underwent radiation uneventfully. There was no drug related toxicity. Pain relief was adequate. Conclusion: Tocoferol monoglucoside an effective antioxidant with no significant acute toxicity, when administered in a dose of 1 or 2 gms per oral route. TMG being water-soluble can have global antioxidant and radio protective effects. This needs further clinical evaluation.


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